For millennia, women have been the guardians of a magical object of great power, the Oroboro, a necklace made of snake bones which emits an intense blue glow and has a powerful ancestral energy, whose origin is unknown and is lost in the history of humanity. However, it is always present and transforms the reality and lives of those who find it.

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It is an anthology series project and the Oroboro is the link between the episodes, always starring women who have their lives influenced by this necklace that moves between space and time in the history of mankind to distant and post-apocalyptic futures, changing the destiny of all those who encounter it. The narrative develops in a timeline from the appearance of the Oroboro until its destruction by Akhdá in the last episode.

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The universe of the episodes revolves around current issues that are depicted in the plot as a background for the situations experienced by the characters. The Guardians of Oroboro is a series full of magical elements, in a "collision" between the fantasy dimension and the concrete world, whose fantastic elements move alongside the possible and real scenarios.